Aluminum(III) Chloride → HCID 23364305, compound

Participants

Reaction Steps

Aluminiumchloride, 1.75 g (13.16 mmol), in 5 ml ether was added to a suspension of lithiumaluminiumhydride, 0.25 g (6.58 mmol), in 3 ml ether during 20 min. 2-methyl-3-(4-methoxybenzoyl)benzofuran, 1.0 g (3.76 mmol), in 10 ml ether was added during 30 min, and the mixture then heated for 45 min. Excess of the reagent was destroyed by adding 0.35 ml H2O, 0.35 ml 1M NaOH and 3 ml H2O to the mixture. Ether, 200 ml, was added, and the organic layer was extracted with 2×100 ml H2O, 2×100 ml 1M sulphuric acid, 100 ml H2O and dried (MgSO4), evaporating gave 0.95 g of 2-methyl-3-(4-methoxybenzyl)benzofuran which was purified on silica.

Provenance & Evidence