(4-hydroxy-3,5-diiodophenyl)-(2-methyl-1-benzofuran-3-yl)methanone → {2,6-Diiodo-4-[(2-methyl-1-benzofuran-3-yl)methyl]phenoxy}acetic acid

HRID 1081312Notes

Reaction equation

HRID 1081312 reaction equation
CC1OC2C=CC=CC=2C=1C(=O)C1C=C(I)C(O)=C(I)C=1.[CH2:22]([C:26]1[O:27][C:28]2[CH:49]=[CH:48][CH:47]=[CH:46][C:29]=2[C:30]=1[C:31](=O)[C:32]1[CH:37]=[C:36]([I:38])[C:35]([O:39][CH2:40][C:41]([OH:43])=[O:42])=[C:34]([I:44])[CH:33]=1)CCC>>[CH3:22][C:26]1[O:27][C:28]2[CH:49]=[CH:48][CH:47]=[CH:46][C:29]=2[C:30]=1[CH2:31][C:32]1[CH:37]=[C:36]([I:38])[C:35]([O:39][CH2:40][C:41]([OH:43])=[O:42])=[C:34]([I:44])[CH:33]=1

Participants

3

Reactant 2

HCID 10164183(4-hydroxy-3,5-diiodophenyl)-(2-methyl-1-benzofuran-3-yl)methanoneHCID 108973252-[4-(2-butyl-1-benzofuran-3-carbonyl)-2,6-diiodophenoxy]acetic acid

Product 1

HCID 9872203{2,6-Diiodo-4-[(2-methyl-1-benzofuran-3-yl)methyl]phenoxy}acetic acid

Procedure

Steps 3 and 4 are performed in analogy with the steps 2 and 3 of the synthesis of (011) Step 5 is performed in analogy with the step 4 of the synthesis of (005).

Sources & evidence

ORD record
ord-94513a37b0e5449dbeb3e8987d6f9a3e
Source dataset
uspto-grants-1996_12
Patent number
US05585404

Reaction notes

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