HCID 9980171, compound → HCID 10792479, compound

HRID 1081314Notes

Reaction equation

HRID 1081314 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]3[C:12](=[N:13][CH:14]=[CH:15][CH:16]=3)[C:11](=[O:18])[N:10]([CH3:19])[C:9]=2[C:20]([N:22]([CH2:24]C2C=CC=CC=2OC)C)=[O:21])=[CH:4][CH:3]=1.[F:33][C:34]([F:49])([F:48])[C:35]1[CH:36]=[C:37]([CH:41]=[C:42]([C:44]([F:47])([F:46])[F:45])[CH:43]=1)[CH2:38]CN>>[F:49][C:34]([F:33])([F:48])[C:35]1[CH:36]=[C:37]([CH:41]=[C:42]([C:44]([F:45])([F:46])[F:47])[CH:43]=1)[CH2:38][N:22]([CH3:24])[C:20]([C:9]1[N:10]([CH3:19])[C:11](=[O:18])[C:16]2[CH:15]=[CH:14][N:13]=[CH:12][C:17]=2[C:8]=1[C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=1)=[O:21]

Participants

3

Reactant 2

HCID 9980171HCID 9980171, compoundHCID 179791832-[3,5-Bis(trifluoromethyl)phenyl]ethan-1-amine

Product 1

HCID 10792479HCID 10792479, compound

Procedure

Employing 4-(4-fluorophenyl)-1,2-dihydro-2-methyl-1-oxo-3-pyrido[4,3-c]pyridine carboxylic acid (Reference Example 4) and N-[3,5-bis(trifluoromethyl)benzyl]methylamine, reaction was allowed to proceed and the reaction mixture was processed in substantially the same manner as in Example 1 to give the above-titled compound as colorless crystals, m.p.136°-138° C. (recrystallized from ethyl acetate-isopropyl ether).

Workup

  1. customto give
  2. customthe above-titled compound as colorless crystals, m.p.136°-138° C. (recrystallized from ethyl acetate-isopropyl ether)

Sources & evidence

ORD record
ord-730f9486664c4a8a98ec0c4b1413d8ef
Source dataset
uspto-grants-1996_12
Patent number
US05585385

Reaction notes

Loading…