HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 6-[N-[3,5-Bis(trifluoromethyl)benzyl]-N-methylamino carbonyl]-5-(4-fluorophenyl)-7,8-dihydro-1,7-dimethyl-8-oxopyrido[3,4-b]pyridinium iodide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | 5-(4-Fluoro-phenyl)-7-methyl-8-oxo-7,8-dihydro-[1,7]naphthyridine-6-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide | HCID 9871891 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 6-[N-[3,5-Bis(trifluoromethyl)benzyl]-N-methylamino carbonyl]-5-(4-fluorophenyl)-7,8-dihydro-1,7-dimethyl-8-oxopyrido[3,4-b]pyridinium iodide | HCID 23364050 | — |
Reaction Steps
A mixture of N-[3,5-bis(trifluoromethyl)benzyl]-5-(4-fluorophenyl)-7,8-dihydro-N, 7-dimethyl-8-oxo-6pyrido[3,4-b]pyridinecarboxamide (Example 1) (175 mg), iodomethane (3 ml) and dioxane (3 ml) was heated for 16 hours under reflux. The solvent was distilled off to leave the above-titled compound as yellow crystals (200 mg), m.p.184°-185° C. (decomp.) (recrystallized from dioxane-ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05585385 |
| Source dataset | uspto-grants-1996_12 |
| ORD ID | ord-9f4e30010ff44cb8b081c9a31566a902 |
| Source note | uspto-grants-1996_12 |