Methyl iodide → HCID 86750069, compound

Participants

Reaction Steps

A mixture of N-[3,5-bis(trifluoromethyl)benzyl]-4-(4-fluorophenyl)-1,2-dihydro-N, 2-dimethyl-1-oxo-3-pyrido[3,4-c]pyridinecarboxamide (Example 8) (240 mg), iodomethane (4 ml) and dioxane (4 ml) was heated for 1.5 hour under reflux. The solvent was distilled off to leave the above-titled compound as yellow crystals (303 mg), m.p.155°-158° C. (decomp.) (recrystallized from dioxane-ethyl ether).

Provenance & Evidence