HCID 11800515, compound → HCID 11800611, compound

Participants

Reaction Steps

To a solution of the compound (270 mg) obtained in Example 8 in acetic acid (15 ml) was added 5% Pt-C (270 mg), and the mixture was stirred for 6 hours at room temperature under hydrogen atmosphere. The catalyst was filtered off, and the filtrate was washed with ethyl acetate. The filtrate and the washing were combined, then the solvent was distilled off. To the residue was added ethyl acetate, and the mixture was washed with an aqueous solution of sodium hydrogencarbonate and water, which was then dried. The solvent was distilled off to leave the above-titled compound as colorless crystals (170 mg). m.p.178°-180° C. (recrystallized from ethyl acetate-ethyl ether)

Provenance & Evidence