反应详情

To a mixture of phthalic anhydride (2.96 g), dichloromethane (10 ml) and aluminum chloride (5.87 g) was added a solution of thiophene (1.6 g) in dichloromethane, in limited amounts, while stirring at room temperature, then the reaction mixture was stirred for one hour at room temperature. The reaction mixture was poured into HCl-ice water, followed by extraction with ethyl acetate. The extract solution was washed with water and dried, then the solvent was distilled off to leave 2-(2-thienylcarbonyl)benzoic acid as colorless crystals (2.72 g).

1. stirringthe reaction mixture was stirred for one hour at room temperature
2. extractionfollowed by extraction with ethyl acetate
3. washThe extract solution was washed with water
4. customdried
5. distillationthe solvent was distilled off