HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1081328Generated: October 26, 2026
Triethylamine → (2-Aminothiophen-3-YL)(4-fluorophenyl)methanone
https://huagongshe.com/reaction/1081328
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1,4-Dithiane-2,5-diol | HCID 98330 | — |
| Reactant | p-Fluorobenzoylacetonitrile | HCID 2783172 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (2-Aminothiophen-3-YL)(4-fluorophenyl)methanone | HCID 11074943 | 116.6% |
Reaction Steps
A mixture of 4-fluorobenzoylacetonitrile (2.84 g), 2,5-dihydroxy-1,4-dithian (1.31 g), triethylamine (2.2 ml) and ethanol (15 ml) was stirred for 40 minutes at 50° C. The reaction mixture was cooled to give 2-amino-3-(4-fluorobenzoyl)thiophene as yellow crystals (2.22 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05585385 |
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| Source dataset | uspto-grants-1996_12 |
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| ORD ID | ord-4b7be0d1bb0146f59fbbcff5ad2a712d |
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| Source note | uspto-grants-1996_12 |
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