Sodium Hydroxide → HCID 19700938, compound

Participants

Reaction Steps

To a mixture of 3-(4-methylbenzoyl)-2-pyridinecarboxylic acid (6.0 g) and 0.1N-NaOH (340 ml) was added portionwise KMnO4 (8.0 g), while stirring at room temperature. After this mixture was heated at 90°-100° C. for 1.5 hour, isopropanol was added to the mixture, and the resulting precipitate was filtered off. To the filtrate was added c.HCl to adjust the pH 2. The solution was saturated with NaCl and extracted with ethyl acetate-THF (about 3:1). The extract was washed with ag. NaCl, dried, and the solvent was evaporated to give 3-(4-carboxybenzoyl)-2-pyridinecarboxylic acid as colorless crystals (1.50 g).

Provenance & Evidence