Glycine, N-methyl-, ethyl ester → HCID 23364092, compound

HRID 1081338Notes

Reaction equation

HRID 1081338 reaction equation
[C:1]([C:4]1[CH:20]=[CH:19][C:7]([C:8]([C:10]2[C:11]([C:16]([OH:18])=O)=[N:12][CH:13]=[CH:14][CH:15]=2)=[O:9])=[CH:6][CH:5]=1)([OH:3])=O.[CH2:21]([O:23][C:24](=[O:28])[CH2:25][NH:26][CH3:27])[CH3:22]>>[CH2:21]([O:23][C:24]([CH2:25][N:26]([CH3:27])[C:16]([C:11]1[C:10]([C:8](=[O:9])[C:7]2[CH:6]=[CH:5][C:4]([C:1](=[O:3])[N:26]([CH2:25][C:24]([O:23][CH2:21][CH3:22])=[O:28])[CH3:27])=[CH:20][CH:19]=2)=[CH:15][CH:14]=[CH:13][N:12]=1)=[O:18])=[O:28])[CH3:22]

Participants

3

Reactant 2

HCID 95849Glycine, N-methyl-, ethyl esterHCID 19700938HCID 19700938, compound

Product 1

HCID 23364092HCID 23364092, compound

Procedure

Using the compound obtained in Step 1 (1.46 g) and N-methylglycine ethylester (3.0), substantially the same reaction and work-up as in Reference Example 2-Step 2 were conducted to give N-ethoxycarbonylmethyl-3-[4-(N-ethoxycarbonylmethyl-N-methylcarbamoyl)benzoyl]-N-methyl-2-pyridinecarboxamide as a colorless oil (2.5 g)

Workup

  1. customsubstantially the same reaction

Sources & evidence

ORD record
ord-6f967c2de9b948f3ad63f0169484a638
Source dataset
uspto-grants-1996_12
Patent number
US05585385

Reaction notes

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