Benzyloxyacetyl chloride → HCID 53875035, compound

HRID 1081381Notes

Reaction equation

Cl.[CH3:2][O:3][C:4](=[O:33])[C@H:5]([CH2:29][CH2:30][S:31][CH3:32])[NH:6][C:7](=[O:28])[CH2:8][N:9]([CH2:21][C@@H:22]([NH2:27])[CH:23]([CH3:26])[CH2:24][CH3:25])[CH2:10][C:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[CH:13][CH:12]=1.[CH2:34]([O:41][CH2:42][C:43](Cl)=[O:44])[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1>>[CH3:2][O:3][C:4](=[O:33])[C@H:5]([CH2:29][CH2:30][S:31][CH3:32])[NH:6][C:7](=[O:28])[CH2:8][N:9]([CH2:21][C@@H:22]([NH:27][C:43](=[O:44])[CH2:42][O:41][CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)[C@@H:23]([CH3:26])[CH2:24][CH3:25])[CH2:10][C:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[CH:13][CH:12]=1

Participants

Reactant 2

HCID 177085Benzyloxyacetyl chloride

HCID 67553617HCID 67553617, compound

Product 1

HCID 53875035HCID 53875035, compound

Procedure

The title compound was prepared from N-[2(S)-amino-3-methylpentyl)-N-(1-naphthylmethyl)-glycyl-methionine methyl ester hydrochloride (Example 1, Step E) and benzyloxyacetyl chloride (Aldrich) under standard conditions.

Sources & evidence

ORD record: ord-4d5e2bf32e7d4e7a8172aaa8e48729bd
Source dataset: uspto-grants-1996_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05585359

Reaction notes

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