HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-(Benzyl(tert-butoxycarbonyl)amino)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Di-tert-butyl dicarbonate | HCID 90495 | — |
| Reactant | Ethyl 2-(benzylamino)acetate Hydrochloride | HCID 2724714 | — |
| Reactant | Ethyl 2-(benzyl((tert-butoxy)carbonyl)amino)acetate | HCID 10565655 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(Benzyl(tert-butoxycarbonyl)amino)acetic acid | HCID 10515816 | — |
Reaction Steps
N-Benzylglycine ethyl ester hydrochloride was converted to N-benzyl-N-t-butoxycarbonylglycine ethyl ester using di-t-butyl dicarbonate under standard conditions. The ethyl ester was saponified using sodium hydroxide in methanol to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05585359 |
| Source dataset | uspto-grants-1996_12 |
| ORD ID | ord-da4e1c553f324bf9971174c0f9e41d69 |
| Source note | uspto-grants-1996_12 |