反应详情

6.4 g (0.03 mol) of (E)-3-chloro-2-fluoro-cinnamamide oxime are introduced into 50 ml of acetic anhydride and the mixture is stirred for 2 hours at reflux temperature. The entire batch is subsequently concentrated in vacuo, the residue is stirred with sodiumcarbonate solution and the mixture is extracted with methylene chloride. The organic phase is dried over sodium sulphate and the solvent is distilled off. 5.1 g (75.6 % of theory) of (E)-3-(3-chloro-2-fluoro-styryl)-5-methyl-1,2,4-oxadiazole are obtained.

1. temperatureat reflux temperature
2. concentrationThe entire batch is subsequently concentrated in vacuo
3. stirringthe residue is stirred with sodiumcarbonate solution
4. extractionthe mixture is extracted with methylene chloride
5. dry with materialThe organic phase is dried over sodium sulphate
6. distillationthe solvent is distilled off