HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 2,3,4,5-Tetrafluoro-6-methylbenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2,3,4,5-Tetrafluoro-6-methylbenzoic acid | HCID 12943997 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2,3,4,5-Tetrafluoro-6-methylbenzoyl chloride | HCID 14651256 | 98.6% |
Reaction Steps
A solution of 8.2 g (39.4 mmol) of 2,3,4,5-tetrafluoro-6-methylbenzoic acid, 6.0 g (47.2 mmol) of oxalyl chloride, and 100 mL of dichloromethane was treated with three drops of DMF. The solution was stirred for 3 hours, then concentrated to give 8.8 g of the title compound as a yellow liquid. The product was used as is in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05585491 |
| Source dataset | uspto-grants-1996_12 |
| ORD ID | ord-5d05344005574118b5d716446c84e88d |
| Source note | uspto-grants-1996_12 |