化工社化工社 化学情報印刷レポート · 研究参考用
Ethyl orthoformate → Ethyl 2-(2-methyl-3,4,5,6-tetrafluorobenzoyl)3-ethoxyacrylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl orthoformate | HCID 31214 | — |
| 反応物 | Ethyl 6-methyl-2,3,4,5-tetrafluorobenzoylacetate | HCID 14774100 | — |
| 溶媒 | Acetic Anhydride | HCID 7918 | — |
| 生成物 | Ethyl 2-(2-methyl-3,4,5,6-tetrafluorobenzoyl)3-ethoxyacrylate | HCID 54293321 | 93.6% |
反応手順
A solution of 8.1 g (29.1 mmol) of ethyl 3-(2, 3,4,5-tetrafluoro-6-methylphenyl)-β-oxopropanoate, 7.2 g (43.3 mmol) of triethyl orthoformate, and 70 mL of acetic anhydride was refluxed for 3.5 hours. The solution was cooled to room temperature and concentrated under high vacuum to give 9.1 g of the title compound. The product was used as is in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05585491 |
| 出典データセット | uspto-grants-1996_12 |
| ORD ID | ord-112a784f8ed246118c2623f602fc41d8 |
| 出典メモ | uspto-grants-1996_12 |