反应详情

温度

5 °C

To a solution of 9.0 g (27.0 mmol) of ethyl 2- (2, 3, 4, 5-tetrafluoro-6-methylbenzoyl)-3-ethoxyacrylate in 30 mL of absolute ethanol at 5° C. was added 1.68 g (29.4 mmol) of cyclopropylamine. The mixture was stirred at 5° C. for 1.5 hours and at room temperature for 2.5 hours. The solution was concentrated to an oil which was triturated with hexane to give a tan solid. The crude product was recrystallized from hexane to give 9.07 g of the title compound, mp 72°-74° C.

1. concentrationThe solution was concentrated to an oil which
2. customwas triturated with hexane
3. customto give a tan solid
4. customThe crude product was recrystallized from hexane