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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 10814Generated: October 25, 2026

Cyanamide → 3-{4-Amino-2-[4-(4-isopropyl-piperazin-1-yl)-phenylamino]-thiazole-5-carbonyl}-benzonitrile

https://huagongshe.com/reaction/10814

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCyanamideHCID 9864—
Reactant3-(2-Bromoacetyl)benzonitrileHCID 2735867—
Reactant1-(4-Isothiocyanatophenyl)-4-(1-methylethyl)piperazineHCID 9878386—
Product3-{4-Amino-2-[4-(4-isopropyl-piperazin-1-yl)-phenylamino]-thiazole-5-carbonyl}-benzonitrileHCID 21958907—

Reaction Steps

This compound was prepared from cyanamide, 1-(4-isothiocyanatophenyl)-4-isopropypiperazine (of Example 3) and 3-cyanophenacyl bromide (Maybridge Chemical Co. Ltd.) following the procedure used in Example 24. Mass spectrum (ES) MH+=447.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07094896B2
Source datasetuspto-grants-2006_08
ORD IDord-3c6803e0976a49bba12682bb51f30c25
Source noteuspto-grants-2006_08