Acetic Anhydride → Ethyl 2-(2,4,5-trifluoro-6-methylbenzoyl)-3-ethoxyacrylate

Participants

Reaction Steps

A solution of 7.1 g (27 mmol) of ethyl (3-2 (2,4,5-trifluoro-6-methylbenzoyl)-β-oxopropanoate, 6.8 g (41 mmol) of triethyl orthoformate and 60 mL of acetic anhydride was refluxed for 3 hours, cooled to room temperature, and concentrated to give 8.4 g of the title compound. The crude material was used as is in the next step.

Provenance & Evidence