Cycloheptylamine → HCID 22922481, compound

Participants

Reaction Steps

A mixture of 18.2 g of 4-chloro-1,2-dinitrobenzene and 31 g of cycloheptylamine in 55 ml of 95° EtOH is stirred for 15 hours at RT. The reaction mixture is concentrated under vacuum, the residue is extracted with AcOEt, washed with a 1N solution of HCl and with water and dried over Na2SO4 and the solvent is evaporated off under vacuum. The residue is chromatographed on silica using petroleum ether as the eluent to give 13 g of the expected product after crystallization from isopropanol.

Provenance & Evidence