2-Chloroaniline → HCID 22922546, compound

Participants

Reaction Steps

A mixture of 101 g of 4-chloro-1,2-dinitrobenzene and 191 g of 2-chloroaniline in 750 ml of 95° EtOH is refluxed for 96 hours. The solvent is evaporated off under vacuum, the residue is extracted with DCM, washed with a 3 N solution of HCl and with water and dried over Na2SO4 and the solvent is evaporated off under vacuum. The residue is chromatographed on silica using a DCM/hexane mixture (50/50; v/v) as the eluent to give 7 g of the expected product after crystallization from EtOH. M.p.=97° C.

Provenance & Evidence