HuagongsheHuagongshe Chemistry Print Report · For research reference only
Amantadine → HCID 4540425, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Amantadine | HCID 2130 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Chloro-1,2-dinitrobenzene | HCID 33097 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 4540425 | HCID 4540425 | 23.1% |
Reaction Steps
15.5 ml of triethylamine and then a suspension of 15 g of 1-aminoadamantane in 50 ml of 96° EtOH are added to a solution of 20 g of 4-chloro-1,2-dinitrobenzene in 80 ml of 96° EtOH. The mixture is refluxed for 7 hours and, after cooling, the precipitate formed is filtered off to give 7 g of the expected product. M.p.=146° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05585394 |
| Source dataset | uspto-grants-1996_12 |
| ORD ID | ord-1a5620f6e61f46d0bf1b549557af3abd |
| Source note | uspto-grants-1996_12 |