Pyridine → HCID 15231548, compound

Participants

Reaction Steps

0.46 g of the compound prepared in Example 5 step B), 20 ml of DCM and 0.5 g of pyridine were mixed at 20° C. and 0.18 g of 2-methylbenzoyl chloride in 10 ml of DCM was then added. The reaction mixture was stirred for 16 hours and then concentrated under vacuum. The residue was washed with water, with 1N hydrochloric acid, with 10% sodium carbonate and then with water. It was dried over sodium sulfate and the solvent was then evaporated off to dryness to give the expected product in the form of a white solid, which crystallized from isopropyl ether. m=0.3 g. M.p.=180° C.

Provenance & Evidence