Water → HCID 23364238, compound

Participants

Reaction Steps

0.35 g of sodium hydride as a 60% dispersion in oil is added in portions to a suspension of 2.5 g of 3-(adamant-1-yl)-5-ethoxy-1,3-dihydro-2H-benzimidazol-2-one in 10 ml of THF and 20 ml of DMF and the mixture is stirred for 30 minutes at RT. 2.2 g of 2-methoxy-4-nitrobenzenesulfonyl chloride are then added and the formation of a yellow precipitate is observed. The reaction mixture is poured into iced water and the precipitate obtained is filtered off and washed with water, with 95° EtOH and with ether to give 3.8 g of the expected product. M.p.=231° C.

Provenance & Evidence