HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Octylamine → HCID 23364245, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Octylamine | HCID 61017 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | 5-Ethoxy-1,3-dihydro-1-(2-methoxy-4-carboxybenzenesulfonyl)-3-cyclohexyl-2H-benzimidazol-2-one | HCID 15229042 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 23364245 | HCID 23364245 | — |
Reaction Steps
A mixture of 0.620 g of the compound obtained in EXAMPLE 13, 1 ml of 1,1,3,3-tetramethylbutylamine, 0.7 g of BOP, 1 ml of DIPEA and 20 ml of DCM is stirred for 2 hours at RT. The reaction mixture is then washed with water, with a 1N solution of HCl and with a 1N solution of NaOH and dried over Na2SO4 and the solvent is evaporated off under vacuum. The residue is chromatographed on silica using DCM as the eluent to give 0.28 g of the expected product in the form of white crystals. M.p.=180° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05585394 |
| Source dataset | uspto-grants-1996_12 |
| ORD ID | ord-22543f02b03b4f51b8994e8c9f0140f0 |
| Source note | uspto-grants-1996_12 |