Phosphorus oxychloride → HCID 23362616, compound

Participants

Reaction Steps

Four (4) g of the above Compound C was mixed with 20 ml of phosphoryl chloride, and the mixture was refluxed for 30 minutes. Then, the phosphoryl chloride was recovered, and the residue was poured into water. After neutralization with potassium carbonate, the system was extracted with dichloromethane and the extract was dried with sodium sulfate. After distilling the solvent off, the extract was purified by means of column chromatography to provide 3.9 g of 2(4-octyloxyphenyl)-4-chloro-5-ethoxycarbonylpyrimidine (Compound D).

Provenance & Evidence