Hydrochloric Acid → HCID 13955485, compound

Participants

Reaction Steps

An eggplant type flask was charged with 2.6 g of the above Compound E, 0.8 g of potassium hydroxide, 45 ml of ethanol and 5 ml of water. The system was refluxed for one hour, and the resultant reaction liquid was poured into 100 ml of water, which was made acidic with hydrochloric acid and extracted with chloroform. The extract was dried over sodium sulfate, removed the solvent by distillation, and recrystallized with 50 ml of hexane. The crystalline product was recovered by filtration, and dried to provide 2.3 g of the object 2-(4-octyloxyphenyl)pyrimidine-5-carboxylic acid, which was the object product.

Provenance & Evidence