Trifluoroacetic acid → HCID 178496724, compound

Participants

Reaction Steps

A solution of 2-bromo-4-tert-butylcarbonyl-7α-methoxy-3-methyl-3-cephem 1,1-dioxide (110 mg) in acetonitrile (100 ml) was treated with 4-[(6-benzhydryloxy-2,5-dihydro-2-methyl-5-oxo-1,2,4- triazin-3-yl)thiomethyl]benzoic acid siver salt (230 mg). The reaction mixture was stirred at room temperature for 30 minutes, then diluted with EtOAC, filtered and rotoevaporated. Upon purification of the residue by flash chromatography 4-tert-butylcarbonyl-2-{4-[(6-benzhydryloxy-2,5-dihydro-2-methyl-5-oxo-1,2,4-triazin-3-yl)thiomethyl]benzoyloxy}-7α-methoxy-3-methyl-3-cephem 1,1-dioxide was obtained as a white solid (mg 75). This product was dissolved in methylene chloride (0.5 ml) and sequentially treated with anisole (0.03 ml) and trifluoroacetic acid (0.5 ml).

Provenance & Evidence