Homophthalic anhydride → 1,3(2H,4H)-isoquinolinedione

Participants

Reaction Conditions

Reaction Steps

Homophthalic anhydride (1.62 g, 10 mmol) and ammonium carbonate (1.61 g, 10 mmol) are ground in a mortar and then slowly heated to fusion at about 280° C. After 2 h, the reaction mixture is allowed to cool. The product is practically pure and needs no further treatment. Thus homophthalimide is obtained in 95% yield (153 mg).

Provenance & Evidence