HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2,4-Diamino-6-chloro-5-(2,4-dichlorophenyl)-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4,6-Dichloro-5-(2,4-dichlorophenyl)pyrimidin-2-amine | HCID 19705054 | — |
| Catalyst | Copper | HCID 23978 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2,4-Diamino-6-chloro-5-(2,4-dichlorophenyl)-pyrimidine | HCID 19705126 | 25% |
Reaction Conditions
| Temperature | 180 °C |
|---|
Reaction Steps
A mixture of 2-amino-5-(2,4-dichlorophenyl)-4,6-dichloropyrimidine (0.5 g) (Example 32) EtOH saturated with ammonia (20 ml) and copper powder (0.05 g) was heated in an autoclave at 180° C. for 18 hours. The cooled reaction mixture was filtered, evaporated and the residue purified by flash column chromatography to give the title compound (0.12, 25%), mp. 219° C. Microanalysis:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05587380 |
| Source dataset | uspto-grants-1996_12 |
| ORD ID | ord-46d1bcea15df4bca954be2bc168c93f2 |
| Source note | uspto-grants-1996_12 |