2-Chloromethyl-3-methyl-4-[2-(4-methyl-5-thiazolyl)ethylthio]pyridine hydrochloride → 2-{[[3-Methyl-4-[2-(4-methyl-5-thiazolyl)-ethylthio]-2-pyridinyl]methyl]thio}-1H-benzimidazole
Reaction equation
[SH:1][C:2]1[NH:6][C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[N:3]=1.Cl.Cl[CH2:13][C:14]1[C:19]([CH3:20])=[C:18]([S:21][CH2:22][CH2:23][C:24]2[S:28][CH:27]=[N:26][C:25]=2[CH3:29])[CH:17]=[CH:16][N:15]=1>>[CH3:20][C:19]1[C:14]([CH2:13][S:1][C:2]2[NH:6][C:5]3[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=3[N:3]=2)=[N:15][CH:16]=[CH:17][C:18]=1[S:21][CH2:22][CH2:23][C:24]1[S:28][CH:27]=[N:26][C:25]=1[CH3:29]Participants
3
Procedure
Following the procedure described in Example 1, the reaction of 2-mercapto-1H-benzimidazole with 2-chloromethyl-3-methyl-4-[2-(4-methyl-5-thiazolyl)ethylthio]pyridine hydrochloride gives the title compound as a colorless solid of m.p. 150°-152° C. following crystallization from dichloromethane/diisopropyl ether.
Sources & evidence
- ORD record
- ord-5d27208d28a649fe933ba136f5b503c3
- Source dataset
- uspto-grants-1996_12
- Patent number
- US05587389
Reaction notes
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