Ethanol → HCID 23363024, compound

HRID 1081673Notes

Reaction equation

HRID 1081673 reaction equation
Cl.Cl[CH2:3][C:4]1[CH:9]=[C:8]([S:10][CH2:11][C:12]2[S:13][CH:14]=[CH:15][CH:16]=2)[CH:7]=[CH:6][N:5]=1.[SH:17][C:18]1[NH:22][C:21]2[CH:23]=[CH:24][CH:25]=[CH:26][C:20]=2[N:19]=1.[OH-].[Na+].[CH2:29]([OH:31])C>>[CH3:29][O:31][C:9]1[C:4]([CH2:3][S:17][C:18]2[NH:22][C:21]3[CH:23]=[CH:24][CH:25]=[CH:26][C:20]=3[N:19]=2)=[N:5][CH:6]=[CH:7][C:8]=1[S:10][CH2:11][C:12]1[S:13][CH:14]=[CH:15][CH:16]=1

Participants

5

Reactant 4

HCID 702EthanolHCID 14798Sodium HydroxideHCID 23363037HCID 23363037, compoundHCID 178527775HCID 178527775, compound

Product 1

HCID 23363024HCID 23363024, compoundYield 69%

Procedure

2-Chloromethyl-4-(2-thienylmethylthio)-pyridine hydrochloride, 2-mercapto-1H-benzimidazole and sodium hydroxide are reacted in ethanol at 60° C. for 5 h. After crystallization from toluene/methanol, the title compound is isolated. Yield: 69%, m.p. 221°-222° C. (decomp.). 9. 2-{[[4-(2-Furylmethylthio)-2-pyridinyl]methyl]thio}-1H-benzimidazole

Workup

  1. customAfter crystallization from toluene/methanol

Sources & evidence

ORD record
ord-cf14fd9ee5a04ba589f87f53e3017705
Source dataset
uspto-grants-1996_12
Patent number
US05587389

Reaction notes

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