反应详情

To a solution of 4.1 g of 8-tert-butoxycarbonylamino-6-[1-(R)-phenylethyl]-6-azaspiro[3.4]octane in 60 ml of ethanol there was added 4.5 g of 5% palladium on charcoal (50% wet) and reduction was carried out under a hydrogen atmosphere (H2 pressure: 4 atm.) for 5 hrs. During the reduction, the reaction vessel was warmed by irradiation with a tungsten lamp. At 1 hr. from the beginning of the reduction, 2 g of the same catalyst was further added and the reduction continued for an additional 4 hours at the same condition to total 5 hours. The catalyst was removed by filtration and the solvent was removed under reduced pressure to yield 2.88 g of the titled compound.

1. customfor 5 hrs
2. temperatureDuring the reduction, the reaction vessel was warmed by irradiation with a tungsten lamp
3. waitthe reduction continued for an additional 4 hours at the same condition to total 5 hours
4. customThe catalyst was removed by filtration
5. customthe solvent was removed under reduced pressure