反应详情

To a solution of 5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine dihydrochloride (2.66 g, 10 mmoles) and triethylamine (4.32 ml, 31 mmoles) in N,N-dimethylformamide (24 ml) was added acetyl chloride (0.71 ml, 10 mmoles) under ice-cooling with stirring and the mixture was stirred at room temperature for 4 hours. The reaction mixture was poured into water and extracted with chloroform. The chloroform layer was washed with saturated saline and dried over anhydrous magnesium sulfate. After the solvent was distilled off, the residue was purified by column chromatography (eluent: ethanol/ethyl acetate=1:3) to obtain 1.57 g of the desired product (66.8%, colorless crystals).

1. temperaturecooling
2. stirringthe mixture was stirred at room temperature for 4 hours
3. extractionextracted with chloroform
4. washThe chloroform layer was washed with saturated saline
5. dry with materialdried over anhydrous magnesium sulfate
6. distillationAfter the solvent was distilled off
7. customthe residue was purified by column chromatography (eluent: ethanol/ethyl acetate=1:3)