反应详情

To a solution of 5-[2-[2-(hydroxy)benzoylamino]ethylthio]imidazo[1,2-a]pyridine (627 mg, 2.00 mmoles) in dry tetrahydrofuran (30 ml) was added 1,1'-carbonyldiimidazole (649 mg, 4.00 mmoles) and the mixture was stirred at room temperature for 15 hours. After the solvent was distilled off, chloroform was added to the residue, which was washed with water and dried over anhydrous magnesium sulfate. After the solvent was distilled off, the residue was purified by column chromatography (eluent:ethyl acetate) to obtain 528 mg of the desired product (77.8%, colorless crystals).

1. distillationAfter the solvent was distilled off
2. additionchloroform was added to the residue, which
3. washwas washed with water
4. dry with materialdried over anhydrous magnesium sulfate
5. distillationAfter the solvent was distilled off
6. customthe residue was purified by column chromatography (eluent:ethyl acetate)