反应详情

A solution of 5-[2-(isopropyloxycarbonylamino)ethylthio]imidazo[1,2-a]pyridine (279 mg, 1 mmoles) in methanol (10 ml) was treated with hydrogen chloride-methanol. After the solvent was distilled off, the residue was crystallized from isopropanol-ethyl acetate-methanol. The crystals thus obtained were washed with water and dried to obtain 290 mg of the desired product (92.1%, colorless crystals).

1. distillationAfter the solvent was distilled off
2. customthe residue was crystallized from isopropanol-ethyl acetate-methanol
3. customThe crystals thus obtained
4. washwere washed with water
5. customdried