Hydrochloride methanol → 5-[2-(Isopropyloxycarbonylamino)ethylthio]imidazo[1,2-a]pyridine hydrochloride

HRID 1081758Notes

Reaction equation

HRID 1081758 reaction equation
[CH:1]([O:4][C:5]([NH:7][CH2:8][CH2:9][S:10][C:11]1[N:16]2[CH:17]=[CH:18][N:19]=[C:15]2[CH:14]=[CH:13][CH:12]=1)=[O:6])([CH3:3])[CH3:2].[ClH:20].CO>CO>[ClH:20].[CH:1]([O:4][C:5]([NH:7][CH2:8][CH2:9][S:10][C:11]1[N:16]2[CH:17]=[CH:18][N:19]=[C:15]2[CH:14]=[CH:13][CH:12]=1)=[O:6])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 233628125-[2-(Isopropyloxycarbonylamino)ethylthio]imidazo[1,2-a]pyridine

Product 1

HCID 233628775-[2-(Isopropyloxycarbonylamino)ethylthio]imidazo[1,2-a]pyridine hydrochlorideYield 92.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 5-[2-(isopropyloxycarbonylamino)ethylthio]imidazo[1,2-a]pyridine (279 mg, 1 mmoles) in methanol (10 ml) was treated with hydrogen chloride-methanol. After the solvent was distilled off, the residue was crystallized from isopropanol-ethyl acetate-methanol. The crystals thus obtained were washed with water and dried to obtain 290 mg of the desired product (92.1%, colorless crystals).

Workup

  1. distillationAfter the solvent was distilled off
  2. customthe residue was crystallized from isopropanol-ethyl acetate-methanol
  3. customThe crystals thus obtained
  4. washwere washed with water
  5. customdried

Sources & evidence

ORD record
ord-af50c8f9d923431a9518eda32421a3d6
Source dataset
uspto-grants-1996_12
Patent number
US05587383

Reaction notes

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