Fluorocinnamic acid → 1,3-diethyl-8-[(E)-1-fluoro-2-phenylethenyl]-7H-purine-2,6-dione

Participants

Reaction Steps

Substantially the same procedure as in Example 7 was repeated using 1.08 g (5.47 mmol) of 5,6-diamino-1,3-diethyluracil and 1.00 g (6.02 mmol) of α-fluorocinnamic acid. Then, the resultant crude crystals were recrystallized from dioxane/water to give 1.04 g (yield 58%) of Compound 138 as white plates.

Provenance & Evidence