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3-Trifluoromethylcinnamic acid → 1H-Purine-2,6-dione, 3,7-dihydro-1,3-diethyl-8-(2-(3-(trifluoromethyl)phenyl)ethenyl)-, (E)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Trifluoromethylcinnamic acid | HCID 85527 | — |
| 反応物 | 5,6-Diamino-1,3-diethyluracil | HCID 4572133 | — |
| 生成物 | 1H-Purine-2,6-dione, 3,7-dihydro-1,3-diethyl-8-(2-(3-(trifluoromethyl)phenyl)ethenyl)-, (E)- | HCID 6448932 | 44% |
反応手順
Substantially the same procedure as in Example 7 was repeated using 2.50 g (12.6 mmol) of 5,6-diamino-1,3-diethyluracil and 3.0 g (13.9 mmol) of 3-trifluoromethylcinnamic acid. Then, the resultant crude crystals were recrystallized from acetonitrile/water to give 2.07 g (yield 44%) of Compound 156 as white needles.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05587378 |
| 出典データセット | uspto-grants-1996_12 |
| ORD ID | ord-0eec740b3ae9443580e5340492854853 |
| 出典メモ | uspto-grants-1996_12 |