Dimethyl Sulfate → HCID 23363109, compound

Participants

Reaction Steps

5-Chloro-2-nitro-N-trifluoroacetylaniline (38 g) from Example 8 was dissolved in acetone (300 ml), followed by addition of potassium carbonate (19.5 g). To the mixture was added dropwise dimethyl sulfate (13.4 ml) for subsequent stirring for 1.5 hours. After filtering off insoluble inorganic materials, the resulting material was washed with ethyl acetate. Removal of the solvent under reduced pressure, hexane was added to the residue under stirring, to separate the crystal by filtration. By washing the crystal further with ether-hexane mixture solution, the title compound was given (33 g; 83.5%).

Provenance & Evidence