1H-1,2,4-Triazole → 2-(1H-1,2,4-triazol-1-ylmethyl)-4-(trifluoromethyl)phenol

HRID 1081877Notes

Reaction equation

HRID 1081877 reaction equation
O[CH2:2][C:3]1[CH:8]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:6]=[CH:5][C:4]=1[OH:13].[NH:14]1[CH:18]=[N:17][CH:16]=[N:15]1>>[N:14]1([CH2:2][C:3]2[CH:8]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:6]=[CH:5][C:4]=2[OH:13])[CH:18]=[N:17][CH:16]=[N:15]1

Participants

3

Reactant 2

HCID 92571H-1,2,4-TriazoleHCID 233631292-(Hydroxymethyl)-4-(trifluoromethyl)phenol

Product 1

HCID 233631492-(1H-1,2,4-triazol-1-ylmethyl)-4-(trifluoromethyl)phenol

Procedure

Following Example 21, the title compound was synthesized (1.55 g; 45%) from 2-hydroxymethyl-4-(trifluoromethyl)phenol (2.7 g) from Example 61 and 1H-1,2,4-triazole (1.07 g).

Sources & evidence

ORD record
ord-a2f7acbe1c82424c926bc35401da8775
Source dataset
uspto-grants-1996_12
Patent number
US05587392

Reaction notes

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