反应详情

2-Bromo-5-chlorobenzaldehyde (20.5 g) from Example 72 was dissolved with dry methanol (200 ml), followed by sodium borohydride (1.06 g) at 0° C., and the mixture was stirred for 30 minutes. After addition of acetone, the solvent was removed under reduced pressure, water was added the obtained residue, and then extracted with ether. The organic layer was washed with saturated sodium hydrogencarbonate solution and saturated sodium chloride solution, and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure, to give the title compound (19.5 g; 94%)

1. customthe solvent was removed under reduced pressure, water
2. additionwas added the obtained residue
3. extractionextracted with ether
4. washThe organic layer was washed with saturated sodium hydrogencarbonate solution and saturated sodium chloride solution
5. dry with materialdried over anhydrous sodium sulfate
6. customThe solvent was removed under reduced pressure