HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 2-Bromo-5-chloro-3-t-butyldimethylsilyloxy-methylbenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | (2-Bromo-5-chlorophenyl)methanol | HCID 23363134 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 2-Bromo-5-chloro-3-t-butyldimethylsilyloxy-methylbenzene | HCID 54035605 | — |
Reaction Steps
To the solution of 2-bromo-5-chlorobenzylalcohol (10 g) from Example 73 and imidazole (3.23 g) in dry DMF (50ml) was added dropwise t-butyl chloro dimethylsilane in dry DMF (10 ml) for 20 minutes at -0° C. After addition, the mixture was stirred for 30 minutes at room temperature. The mixture was diluted with ether, and washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05587392 |
| Source dataset | uspto-grants-1996_12 |
| ORD ID | ord-88b7559467854c518a0df0ac0ab495bd |
| Source note | uspto-grants-1996_12 |