HCID 10389303, compound → HCID 15017910, compound

HRID 1081899Notes

Reaction equation

HRID 1081899 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[N:9]=[C:8]([CH2:10][CH2:11][CH2:12][CH3:13])[N:7]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([C:21]4[C:22]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])=[CH:23][CH:24]=[CH:25][CH:26]=4)=[CH:17][CH:16]=3)[C:6]=2[CH:34]=1.[C:35]1(=[O:46])[O:41][C:39](=[O:40])[CH:38]2[CH2:42][CH2:43][CH2:44][CH2:45][CH:37]2[CH2:36]1>N1C=CC=CC=1>[CH2:10]([C:8]1[N:7]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[C:22]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])=[CH:23][CH:24]=[CH:25][CH:26]=3)=[CH:17][CH:16]=2)[C:6]2[CH:34]=[C:2]([NH:1][C:35]([CH2:36][CH:37]3[CH2:45][CH2:44][CH2:43][CH2:42][CH:38]3[C:39]([OH:41])=[O:40])=[O:46])[CH:3]=[CH:4][C:5]=2[N:9]=1)[CH2:11][CH2:12][CH3:13]

Participants

4

Reactant 2

HCID 10389303HCID 10389303, compoundHCID 23345435HCID 23345435, compound

Product 1

HCID 15017910HCID 15017910, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

1.3 g (2.86 mMol) of tert.-butyl 4'-[(6-amino-2-n-butyl-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylate, 0.6 g (5.35 mMol) of hexahydrohomophthalic acid anhydride and 5 ml of pyridine are refluxed with stirring for 3 hours. Then the pyridine is removed by rotary evaporation in vacuo, the residue is crystallised from acetone, washed with acetone and dried in vacuo at 70° C.

Workup

  1. customThen the pyridine is removed by rotary evaporation in vacuo
  2. customthe residue is crystallised from acetone
  3. washwashed with acetone
  4. customdried in vacuo at 70° C.

Sources & evidence

ORD record
ord-0e5e73eda90b4ae3ac6a16dd2015f8ed
Source dataset
uspto-grants-1996_12
Patent number
US05587393

Reaction notes

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