Water → HCID 131719754, compound

Participants

Reaction Steps

p-Nitrobenzoyl chloride (4.72 g, 25.42 mmol) was added to a solution of cis and trans-2-hydroxymethyl-4-hydroxy-1,3-dithiolane (1.38 g, 9.08 mmol) in dry pyridine (50 mL) at 0° C. the reaction mixture was then placed in the refrigerator for 18 h. The reaction mixture was then poured into water and extracted with methylene chloride (3X). The combined organic extracts were washed with water, brine, dried and concentrated to give a yellow solid, 3.68 g (90%). 1H NMR (CDCl3) (300 MHz) δ: (8.27 (m, 8H, Ar-H), 6.86+6.81 (dd's, 1H, 3Hz, 2Hz, C4-H), 4.96+4.87 (t's, 1H, 7Hz, C2--H), 4.47 (m, 2H, CH2OAr), 3.5 (m, 2H, C5--H).

Provenance & Evidence