Ethanolamine → N-hydroxyethyl-beta-dipropylaminopropionamide

Participants

Reaction Steps

To 746 g of methyl beta-dipropylaminopropionate which was prepared in the same manner as in Example 4 were added 15.4 g of 28% methanolic solution of sodium methoxide, then 293 g (4.8 moles) of ethanolamine were added dropwise thereinto and the mixture was made to react at 70° C. for one hour. After completion of the reaction, the mixture was neutralized, desalted, 0.3 g of phenothiazine were added thereto and the low-boiling-point substances were removed by distillation to give 858 grams of N-hydroxyethyl-beta-dipropylaminopropionamide. The purity as checked by gas chromatography was 98% and the yield was 97.3%.

Provenance & Evidence