8-Aminoquinoline → 8-Quinolinamine, 1,2,3,4-tetrahydro-

Participants

Reaction Conditions

Reaction Steps

25 g (0.169 mol) of quinolin-8-amine are dissolved in 600 ml of ethanol. The reaction mixture is heated to 70° C. and 45 g of sodium are added in small pieces. The mixture is brought to the reflux temperature until the sodium has disappeared. The mixture is then evaporated to dryness and the residue is taken up in an ether/hexane (50/50) mixture, filtered and again evaporated to dryness. 35 g of product are obtained in the form of an oil which is used as is in the following stage.

Provenance & Evidence