反应详情

1 g (0.0052 mol) of 2-chloro-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline, 1.57 g (0.0104 mol) of 4-(1H-imidazol-4-yl)piperidine and 5 ml of isoamyl alcohol are heated at 120° C. for 1 day. The alcohol is then evaporated to dryness, the residue is taken up in a water/ether (50/50) mixture and the product sucked dry. The product is purified by chromatography on a column of silica gel, the eluent being a dichloromethane/methanol/aqueous ammonia (95/5/0.5) mixture, is then triturated in ether and dried under vacuum at 60° C. 1 g of product is obtained.

1. customThe alcohol is then evaporated to dryness
2. customthe product sucked dry
3. customThe product is purified by chromatography on a column of silica gel
4. customis then triturated in ether
5. customdried under vacuum at 60° C