HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluorobenzonitrile → 2-(4-Trifluoromethyl-2-aminophenylthio) benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluorobenzonitrile | HCID 67855 | — |
| Reactant | Dibenzo[b,f][1,4]thiazepine-11(10H)-thione | HCID 667552 | — |
| Reactant | 2-Amino-4-(trifluoromethyl)benzenethiol hydrochloride | HCID 2734678 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(4-Trifluoromethyl-2-aminophenylthio) benzonitrile | HCID 10541803 | — |
Reaction Steps
Using a procedure analagous to that of Example 3(a) and (b), 4-trifluoromethyl-2-aminothiophenol hydrochloride (11.48 g, 50 mmol) was combined with 2-fluorobenzonitrile in DMF solvent (100 ml) to give crude 2-(4-trifluoromethyl-2-aminophenylthio) benzonitrile (6.84 g). Hydrolysis and subsequent condensation gave the title compound as off-white crystals from ethanol (1.1 g, m.p. 233°-235° C., Rf 0.21, CH2Cl2 /MeOH 50:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05589474 |
| Source dataset | uspto-grants-1996_12 |
| ORD ID | ord-ef0b26c4f28f45f1ab0a5bcdc64bfc98 |
| Source note | uspto-grants-1996_12 |