HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexane → 3-Trifluoromethyl-2-(2-aminophenylthio)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexane | HCID 8078 | — |
| Reactant | 2-Aminothiophenol | HCID 8713 | — |
| Reactant | 2-Fluoro-3-(trifluoromethyl)benzonitrile | HCID 518974 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-Trifluoromethyl-2-(2-aminophenylthio)benzonitrile | HCID 19969445 | — |
Reaction Steps
Using a procedure analagous to that of Example 3(a), 2-aminothiophenol (6.26 g, 50 mmol) was combined with 3-trifluoromethyl-2-fluorobenzonitrile (1 eq) in DMF solvent (50 ml) to give the title compound as a white solid from cyclohexane (10.41 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05589474 |
| Source dataset | uspto-grants-1996_12 |
| ORD ID | ord-ae940f8d208346e8bf6e1fa1a5e2df22 |
| Source note | uspto-grants-1996_12 |