反应详情

4,8-Bis(trifluoromethyl)-10,11-dihydrodibenzo[b,f][1,4]thiazepin-11-one (0.54 g) was dissolved in pyridine (15 ml). Phosphorus pentasulphide (0.60 g) was added to the solution and the whole was stirred under reflux for 6 hours, then cooled and left overnight. Addition of water (40 ml) and cooling gave a yellow solid which was filtered off, washed with water and recrystallised from ethanol to give the product as yellow needles (0.26 g, m/s. M- =379).

1. temperatureunder reflux for 6 hours
2. temperaturecooled
3. temperaturecooling
4. customgave a yellow solid which
5. filtrationwas filtered off
6. washwashed with water
7. customrecrystallised from ethanol