Sodium Hydroxide → HCID 23362149, compound

Participants

Reaction Conditions

Reaction Steps

To a solution containing 1.2 g (0.03 mol) of sodium hydroxide in 50 ml of an 50% by volume ethanol/water mixture, 12.41 g (0.03 mol) of 1-(4-chlorophenyl)-3-[4-hydroxy-(4-chlorophenyl)-1-piperidyl]propanone hydrochloride and then, over 1 hour 1.17 g of sodium borohydride are added. The suspension is heated at a temperature of 50° C. for 2 hours. After cooling down, the reaction mixture is filtered and washed with water to give 11.45 g of product, m.p.: 129°-132° C. After recrystallization of the latter product from 215 ml of acetonitrile, 9.1 g of title compound are obtained.

Provenance & Evidence